Men are three times more likely to be admitted to the ICU for covid-19 than women


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Men infected by the SARS-CoV-2 coronavirus who have developed covid-19 have almost three times more likely to require admission to intensive care than women. The study, published in « Nature Communications»Has also seen that male patients have a higher risk of death from COVID-19.

It is known that there is a more severe bias of COVID-19 disease in male patients. However, until now it had not been validated in a large-scale analysis of global data.

In a meta-analysis of 92 reports from January 1, 2020 to June 1, 2020, the team at Instituto Francis Crick (Great Britain) investigated whether sex was a risk factor for SARS-CoV-2 infection and mortality from Covid-19.

In total, their analysis included 3,111,714 cases, in which the sex of patients from 46 countries and 44 US states was recorded.

The authors suggest that differences in the immune responses of different sexes are likely a factor in the results.

The authors found that there was no difference in the proportion of male and female patients who were infected with SARS-CoV-2. However, it has seen that men were more likely (2.84 times more) to require admission to an intensive care unit as a result of COVID-19.

Additionally, the odds of death from COVID-19 were 1.39 times higher for male patients in the study than for females.

The authors suggest that differences in the immune responses of different sexes are likely a factor in the results. Women have a more robust innate antiviral response to interferon and greater adaptive immunity to viral antigens. In people infected with SARS-CoV-2, these differences are likely to lead to more effective viral control in women, which can lead to a relatively lower risk of developing severe disease.

However, they acknowledge that other biological factors and sex-based comorbidities may influence.

They argue that, although more studies are needed, these data have important implications for the clinical management of COVID-19 and highlight the importance of considering sex as a fundamental variable in research and in the clinic.

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