Sat. Dec 4th, 2021


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Inject a Covid-19 vaccine from Pfizer/BioNTech after another of AstraZeneca/Oxford, Y space several months both dose of the latter substantially improve immunity, according to two studies published Monday by the University of Oxford. The researchers showed that, far from reducing the effectiveness of the vaccine, an interval of up to 45 weeks between the two required doses of AstraZeneca / Oxford improves the immune response to the virus.

‘This should be reassuring news for countries with fewer vaccine supplies, which may be concerned about delays in obtaining second doses,’ said Professor Andrew Pollard, director of the Oxford Vaccine Group, which developed the vaccine with the group. Anglo-Swedish pharmacist AstraZeneca. “There is an excellent response to the second dose even 10 months after receiving the first”, he stressed.

Another study from the same university published in February by the prestigious scientific journal in ‘The Lancet’ already indicated that the efficacy of the vaccine was higher with an interval of three months between doses (81%) what with an interval of six weeks (55%).

As a result of this new research, scientists also discovered that a third dose injected more than six months after the second results in a ‘Significant rise’ in antibodies and causes a “strong increase” in the immune response against Covid-19, including against known variants of the coronavirus.

“We do not know whether booster injections will be needed due to decreased immunity or to increase immunity against variants,” said Teresa Lambe, lead author of the study. But he noted that the research shows that a third dose of the vaccine “is well tolerated and significantly increases the response to the level of antibodies.” “This is very encouraging news if a third dose is found to be necessary,” he added.

The researchers also claim that the vaccine caused “fewer side effects after the second and third doses than after the first. ‘

AstraZeneca’s vaccine, which uses a so-called “viral vector” (adenovirus) technology, has raised concern after a link was established between its administration and the development of rare and sometimes fatal thrombi. As a result, many countries restricted its use to older people and some stopped using it.

In a separate study also published this Monday, the University of Oxford also found that combining doses of AstraZeneca / Oxford and its German-American competitor Pfizer / BioNTech, injected four weeks apart, also improves the immune response against Covid-19. .

Order alters effectiveness

Efficacy, however, varies according to the order, according to this study which found that one dose of AstraZeneca / Oxford followed by another of Pfizer / BioNTech generates a “better immune response” than vice versa.

Results for a 12-week interval between the two doses will be available shortly and ‘will be instrumental in deciding the future of the UK vaccination program’, said Professor Jonathan Van-Tam, England’s Deputy Medical Director.

The combination of two different serums “Could give us even more flexibility”, he pointed. In the UK, 84.1% of the adult population have received a first injection and 61.6% the full regimen.

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