Protection against Covid-19 decreases for all types of vaccines


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Protection against Covid-19 decreases for all types of vaccines: from 87.9% in February to 48.1% in October 2021. A study by the Institute of
Veterans Affairs Medical Center Public Health
and the
University of Texas Health Sciences Center (USA)
, published in
«Science»
, which has analyzed the possibility of infection and the ability to protect against Covid of the vaccines of Moderna, Pfizer, Janssen among 780,225 people.

The study shows that the decrease was greater for the vaccine Janssen, which went from a protection of 86.4% in March to 13.1% in September. In the case of PfizerBioNTech, the decrease was from 86.9% to 43.3%, from 89.2% to 58% for Moderna’s vaccine.

While most previous studies had focused on PfizerBioNTech or Moderna vaccines, the study by
«Science»
is the first to compare the decrease in protection in the three main types of vaccines, as well as being the first to show the very significant decrease in the effectiveness of the Janssen vaccine.

The research was developed from February 1, 2021 to October 1, 2021, period that includes the appearance and prevalence of the Delta variant in the United States., the main determinant of the increase in infections and deaths.

However, the researchers note that vaccination of any type protected those who were infected from the risk of death and that this relative benefit was greater in people under 65 years of age, but was also very important in those over 65 years of age.

The study clearly shows that the risk of dying from Covid-19 infection was higher in the unvaccinated, regardless of age and comorbidities.

The study shows that the decrease was greater for the Janssen vaccine, which went from 86.4% protection in March to 13.1% in September. In the case of PfizerBioNTech, the decrease was from 86.9% to 43.3%, from 89.2% to 58% for Moderna’s vaccine.

And despite some deaths, vaccination continued to protect against the disease in those who were infected with the Delta variant.

The results of this work leave no doubt about the protection of the vaccine. Thus, in those under 65 years of age, vaccines in general were 81.7% effective against the risk of death. In addition, protection was higher for the Pfizer vaccine, with 84.3% and Moderna was the next most effective, with 81.5%. While Janssen had an effectiveness of 73%.

As for the over 65 years, the overall effectiveness of the vaccine was 71.6%, the most effective being Moderna (75.5%), followed by Pfizer (70.1%) and Janssen (52.2%).

“Our study provides researchers and health policy makers with a solid basis to compare the long-term effectiveness of vaccines, as well as providing key information in decision-making about primary vaccination, booster doses and other protective measures, including the use of masks, social distancing and other public health interventions in order to reduce the possibility of spread ”, says Barbara Cohn, lead author of the study.

For example, the booster recommendation for all those over 18 years of age who received the Janssen vaccine is supported by these results. And, given declines in vaccine protection and the predominance of the more infectious Delta variant, Cohn adds, “we think that It is important to insist that quick measures be taken to promote initial vaccination, reinforcements and encourage the use of a mask, social distancing and other protection measures against infection.».

The researchers also add that the evidence shows that vaccination continues to protect against death «even to people who become infected while being vaccinated, compared to people who are infected and not vaccinated».

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